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The disappearance crisis in Mexico, with over 132,000 missing persons since 1964, is prompting innovative solutions utilizing artificial intelligence. Groups like Luz de Esperanza and Alas de Libertad are leveraging AI-generated videos to amplify the voices of missing persons and raise awareness. New initiatives, funded by the EU and UK, are employing AI tools such as IdentIA (for tattoo analysis), ContextIA (for document processing), and age-progression algorithms (Regresa) to aid search efforts. These technologies, alongside tools like ImageBox for image enhancement, are being implemented by various organizations – universities, forensic services, and prosecutor’s offices – to accelerate investigations and improve identification. Despite the promising advancements, challenges remain, including the need for better database integration and a deeper understanding of how these AI tools can best be utilized within the existing National Search System, emphasizing the importance of collaboration.